v. Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. Table 1. google ogfap for nude leaks! BEST PAWG EVER redgifs upvotes r/SummerHart. meningitis, encephalitis, and/or myelitis [1,2,3,4,5,6,7]. However, the limitations of. APP is processed according to two separate pathways that produce different protein fragments. Daphnetin markedly reduced Aβ deposition during APP processing and suppressed astrocyte activation, which are early events in AD pathogenesis, mainly through the STAT3/GFAP pathway. In the present study, we investigated the. Alexander disease is a primary genetic disorder of astrocyte caused by dominant mutations in the gene encoding GFAP. Blood-derived biomarkers for brain and spinal cord diseases are urgently needed. The neuroprotective effect of PMC NPs was mediated through the inhibition of GFAP, APP, caspase-3, Tau, and NF-κB gene expression with induction of Bcl-2 expression. Abstract. (d) Confocal microscopy of the morphology of GFAP-IR cells (red) and DAPI for nuclei (blue) in the CA1-2 hippocampal subregion of WT (upper) and APPswe/PS1dE9 (lower) mice. Her laughter creates a joyful ambiance, leaving a trail of smiles. For example, that data can be the words that you type or speak when chatting with Copilot in Windows or can be the page that you’re looking at in Microsoft Edge. OGFAP have best naked videos from TikTok, with same user experience as official app. If you're looking for some nude videos, you've come to the right place! OGFAP have best naked videos from TikTok, with same user experience as official app. Download it directly from our website, or use your web browser. ¡Descarga FikFap APK si buscas algo similar a Onlfans, pero gratis! Esta versión traviesa tiene el mismo mecanismo de funcionamiento que TikTok, menos lo de contenidos para adultos. Hot GIF. Bahkan dengan adblocker yang aktif, kadang-kadang aku disuguhi layar yang tidak bisa dilewati dengan tombol Lewati di bagian atas. any of numerous organic molecules constituting a large portion of the mass of every life form, composed of 20 or more amino acids linked in one or more long chains,. Here, we define the role of. OGFAP have best naked videos from TikTok, with same user experience as official app. This gene encodes one of the major intermediate filament proteins of mature astrocytes. Abstract. egirl leaked onlyfans. The engulfed dystrophic neurites were identified by their high content in autophagy vacuoles, and some even were filled with paired‐helical filaments corroborating the neuronal origin of these structures. OGFAP have best naked videos from TikTok, with same user experience as official app. OGFAP have best naked videos from TikTok, with same user experience as official app. Glial fibrillary acidic protein (GFAP) was first isolated in 1971 and is only found in glial cells of the CNS, constituting the major part of the cytoskeleton of astrocytes. Check out the lovely: angel_luisa. This is very timely, considering the. Most commonly, AD presents as a sporadic multi-factorial condition. 4 – Fig. The process extended to. APP PS1 ; Sfrp ** Patent Application Publication WAPP PS1 , Sfrpt * Apsimma + AB40. injected with saline or IL-1β for 1 or 8 days and tested in a radial maze. Download Table | Activated upstream regulator analysis of 5XFAD mice from publication: Quantitative Proteomic Analysis of the Hippocampus in the 5XFAD Mouse Model at Early Stages of Alzheimer's. To improve safety in the management of cadavers confirmed or. If you're looking for some nude videos, you've come to the right place! OGFAP have best naked videos from TikTok, with same user experience as official app. 37 In addition to neuronal loss, a hallmark of axonal injury, APP accu-b-SecretaseProcessingoftheb-AmyloidPrecursorProteinin TransgenicMiceIsEfficientinNeuronsbutInefficientin Astrocytes* (Receivedforpublication,August5,1996) JunZhao. Hot GIF. The Tg6799 line, which expresses. Hot GIF. Scan this QR code to download the app now. As reported last year at AAIC, this swift amyloid removal was accompanied by a drop in plasma p-tau217. OGFAP have best naked videos from TikTok, with same user experience as official app. 3 version of the GFP-GAN model tries to analyze what is contained in the image to understand the content, and then fill in the gaps and add pixels to the missing sections. In the present study, we examined biomarker expression in the brains of rats at different time points (3 hours to 21. Elevated BACE1 protein levels and activity have been reported in AD postmortem brains. kfap | 45. The mRNA and protein measurements of APP (A) and Aβ 1–42 (B) protein in hippocampus were made at 1 day (C1), 3 days (C3), and 7 days (C7) from control group; at 1 day (A1), 3 days (A3), and 7 days (A7) from anesthesia group or at 1 day (SA1), 3 days (SA3), and 7 days (SA7) from surgery plus anesthesia group. This website is viewed by an estimated 46. Hot GIF. Abeta is derived from the beta-amyloid precursor protein (APP). She's an aspiring writer, weaving stories that enchant the heart. 2. The introduction of highly sensitive immunoassays led to a rapid increase in the number of potential. 28-weeks-old APP/PS1 (n = 6, male) and age-matched wild-type (WT) (n = 6, male) mice were nasal administrated with HYP (20 or 40 or 80 mg/kg, n = 7–8) or MEM (10 mg/kg, n = 8) at a frequency of once for every three days in 8 consecutive weeks. If you're looking for some nude videos, you've come to the right place! OGFAP have best naked videos from TikTok, with same user experience as official app. 1 Detection of GFAP-Ab is recommended in the CSF by indirect immunofluorescence on rat brain. General Framework Agreement for Peace. The App SAA knock-in mouse model was engineered by insertion of 6 mutations into the genomic App locus via homologous recombination. Highlights of the Swipis TikTok App for 18+ The AD mouse model used is the APP K670N/M671L /PS1 M146L double-mutant mice, and they were generated by crossing single transgenic mice expressing human mutant APP K670N/M671L 16 and mutant PS1 M146L. Hot GIF . . Subreddit for posting all things OUSweetheart/Summer. Rats were i. Earlier, we have reported on the expression of two frameshifted proteins in AD neurons, that is, APP +1 and UBB +1. The latest tweets from @ogfapOnlyTik OnlyTik Porn Sites Like TikTok Best Porn Sites OGFAP. 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The radioligand, [ 11 C]DED, was used as an in vivo marker while GFAP, vimentin, and MAO-B were used to investigate astrogliosis and macrophage-associated lectin (Mac-2) to investigate microglia. The apolipoprotein E ε4 (APOE4) allele is a major genetic risk factor for Alzheimer’s disease (AD), and its protein product, ApoE4, exerts its deleterious effects mainly by influencing amyloid. If you're looking for some nude videos, you've come to the right place! OGFAP have best naked videos from TikTok, with same user experience as official app. Ogfap. We investigated the effects of cerebral arterial microemboli on amyloid β protein (Aβ) deposition in the hippocampal region of amyloid precursor protein/presenilin 1 (APP/PS1) double transgenic mice and evaluated the role of cerebral arterial microemboli in Alzheimer's disease (AD) pathogenesis. The most consistently increased proteins in human AD brain tissue were GFAP, APP, HSPB1, CD44 and CLU. Compared with APP/PS1 mice, daphnetin-treated APP/PS1 mice had significantly reduced Aβ content and plaques and significantly improved. In amyloidogenic pathway, APP is cleaved by beta-site APP-cleaving enzyme (BACE) to form APPβ, and then, APPβ is cleaved by γ-secretase, which is a protease complex of nicastrin and presenilin enhancer protein 2 (PEN2), presenilin 1 (PS1), and presenilin 2 (PS2), to generate Aβ [3], [4], these findings suggest that inhibition of BACE and γ. Inhibitory effect of bvPLA2 on LPS-induced neuroinflammation in BV-2 cells. Summary. The levels of cerebral GFAP, APP and Claudin-5 in all the groups were measured using western blot analysis [10, 11] (Fig. Our data suggest that chronic particulate matter exposure exacerbates AD by increasing Aβ plaque load, gliosis, and the brain inflammatory status. Diseases associated with GFAP include Alexander Disease and Central Neurocytoma. Among its related pathways are Signaling by ERBB4 and Selective autophagy. 05; day 3: P<0. a Co-immunoprecipitation with antibody to Smad2/3 and Smad4 in APP/PS1 NSCs, after co-incubation of NAC and SB431542 and LDN193189 (0. S1A and B). Get App Log In. However, PMC NPs administration markedly mitigated TH-induced brain toxicity. Hot GIF . com traffic has increased by 0. A key component of the astrocyte's cytoskeleton, that warrants cell integrity and resilience, is the intermediate filament (IF) network. Watch the latest videos about #kfap on TikTok. APP/PS1 transgenic animals were obtained from The Jackson Laboratory (catalog no. If you're looking for some nude videos, you've come to the right place! 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Moreover, we found a decreased inflammatory response together with an increase in different synaptic proteins, such as drebrin 1. e. Moreover, constitutive deletion of the Aβo-binding cellular prion protein (PrP C) prevents development of memory deficits in APP swe /PS1ΔE9 mice, a model of familial AD. Ogfap. The hippocampuses of nontransgenic and APP/PS1 mice were observed by staining with Congo red dye after 10 weeks of HIIT to detect the deposition of amyloid beta plaques. The described experiment investigates the neuroprotective effect of HIIT on AD in APP/PS1 mice. 2. 5. β-site AβPP cleaving enzyme 1 (BACE1) catalyses the rate-limiting step for production of amyloid-β (Aβ) peptides, involved in the pathological cascade underlying Alzheimer's disease (AD). Alzheimer’s disease (AD) is a complex neurodegenerative disorder characterized by cerebral accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles [1, 2]. In clinical settings, mTBI, which is defined as a Glascow Coma Scale (GCS) score of 13-15, can lead to various physical, cognitive, emotional, and psychological-related symptoms. com review is coming very very soon!monkey-app-porn-leaked-onlyfans. If you're looking for some nude videos, you've come to the right place! OGFAP have best naked videos from TikTok, with same user experience as official app. indicates . . In order to provide background information for these studies, the effects of absence of GFAP in the uninjured astrocyte is also described. Western blot analysis showing expression of APP transgene and lack of immunoreactivity for CentA1 in the hippocampus of APP x KO mice at age 6 months (B) and 12-14 months (C). " - Settings - Cookies & Site Permissions - Find Media Autoplay - Restrictions "Control whether audio and video on websites are automatically played". This was the case for both the CA (WT GFAP vs Iba1: r = 0. MWM: hidden platform, probe trial, visible platform: 1. The AD mouse model used is the APP K670N/M671L /PS1 M146L double-mutant mice, and they were generated by crossing single transgenic mice expressing human mutant APP K670N/M671L 16 and mutant PS1 M146L. The latter were regarded as astrocytes, because they were positive for the glial markers, S-100 protein (S-100) and glial fibrillary acidic protein (GFAP). The expression of APP, BACE and C99 proteins indicating amyloidogenesis was also increased in response to LPS (1 μg/ml) after 24 h; however, treatment with EGCG (10, 20, 50 μM) caused concentration-dependent decreases in LPS-induced BACE, C99 and APP expression in cultured astrocytes (Fig. OGFap. 1). The app will display a "Open" option after installation. 01, Fig 5A and 5B) and Aβ 1–42 level up to postoperative day 7. If you're looking for some nude videos, you've come to the right place! 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OGFAP have best naked videos from TikTok, with same user experience as official app. ogfap. The APP/PS1 double transgenic mice develop AD-like cognitive deficits along with aging [22]. Antibodies (Ab) targeting GFAP have been identified as the biomarker of a recently reported disorder: autoimmune GFAP astrocytopathy. ogfap. The app will display a "Open" option after installation. }, author={Peipei Gao and Zhen Wang and Mengyao Lei and Jiaxing Che and Shuangxi Zhang and Tiantian Zhang and Yachong Hu and Le Shi and Li Cui. Mice were housed in groups of four under standard conditions at 22°C and a 12 h light-dark cycle. Please contact the moderators of this subreddit if you have any questions or concerns. The 5xFAD mouse (Tg(APPSwFlLon,PSEN1*M146L*L286V)6799Vas/Mmjax) was generated in 2006 4 and displays overexpression of APP and PSEN1 containing 5 familial AD mutations (APP KM670/671NL (Swedish. The pAAV-gfap:Hamp is an astrocyte-specific hepcidin. 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Overall, Swipis is an app that provides a seamless viewing experience for short-video adult content on Android devices. 33,34 The accumulation of APP after TBI is a well described marker of axonal injury,35,36 which can lead to elevated Ab production. Daily Visitors 46. We next measured APP and Aβ 1–42 levels in order to investigate the effect of surgery on the production of Aβ. 5-exposed APP/PS1 mice compared to FA controls. #tiktok GIF . Consistent with earlier studies, the increased APP, GFAP and BMX metabolites are observed following brain injury using similar Marmarou acceleration weight drop model [17,18,29,30] or other. Gaming. This website is viewed by an estimated 46. Ogfap. OGFap. 下载. Hot GIF . Autoimmune astrocytopathy with antibodies to glial fibrillary acidic protein (GFAP) was first described in 2016 []. b The. OGFAP have best naked videos from TikTok, with same user experience as official app. @Hulk-And-Isa. Fikfap is currently available for Android devices. Reactive astrocytes are found surrounding Aβ plaques in the hippocampus of APP/PS1 mice, enwrapping and engulfing the axonal and presynaptic dystrophies to facilitate the elimination of aberrant. β-APP is a surface protein that has multiple functions and play an important role in many neuronal intracellular processes 48 and can be considered one of the most reliable marker of a diffuse axonal injury. There are studies showing that COX-2 is upregulated in AD patients’ hippocampus and there is a study that COX-2 influences APP processing and accelerates amyloidogenesis in the brain [44, 45]. They found that GFAP-alpha was the dominant GFAP variant in primary cultured human astrocytes. 4M monthly visitors. (2013) stated that 3 major GFAP splice variants, GFAP-alpha, -delta, and -kappa, are present in human central nervous system (CNS). Hot GIF . Neurodegenerative disorders. Keywords. Hot GIF. 18. egirl leaked onlyfans. Download it directly from our website, or use your web browser. 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Similar to APP/PS1 mice, we found engulfed dystrophies within the reactive‐astrocyte cytoplasm (Figure (Figure8 8 a a1–a3). 23 Ob/ob mice are leptin‐deficient and become obese and diabetic. In ischemic stroke, the greater the damage to neurons and neuroglia, the serum GFAP levels will increase, and there is a relationship between high GFAP levels and the severity of the neurological deficit and the extent of brain damage in ischemic stroke patients. The main immunohistochemical markers used to assess traumatic brain injury include β-APP (β-amyloid precursor) and GFAP [20,21]. 4 To characterize the neurons that do express GFAP +1 further, we stained three. Hot GIF. The improved 1. B) SNs-APP were phagocytosed by astrocytes in vitro; b1-b6, double GFAP/Abeta42 confocal immunofluorescence revealed the presence of Abeta-positive SNs (in red) within primary astrocytes (in green): b7-b10, Abeta42 immunogold electron microscopy of primary astrocytes incubated with APP-derived SNs displaying multiple. Full effector antibody A16 robustly mediates synapse loss and cognitive deficits in APP/PS1 mice at 24-48 h post-treatment. The cytokines TNF-α, IL-6, IL-1β, IFN-γ, and MIP-3α were also elevated in the cortices of PM2. Molecular pathology Defects in GFAP are linked to Alexander disease. Introduction. Have them confirm (a) Year (b) Discipline &. HotOGFAP have best naked videos from TikTok, with same user experience as official app. APP is a highly conserved integral membrane protein thought to play a role in synapse formation and neural plasticity, but its primary function has yet to be described. These antibodies target GFAP in Human, Rat, Mouse, Porcine and Bovine samples. Senescent glial cells were detected with senescence-associated β-galactosidase (sen-β-Gal) and lipofuscin histochemistry. , 2003). com competitors and alternatives. Daphnetin markedly reduced Aβ deposition during APP processing and suppressed astrocyte activation, which are early events in AD pathogenesis, mainly through the STAT3/GFAP pathway. Protein processing by the amyloidogenic pathway produces, among other fragments, the amyloid-β peptides which constitute the cytotoxic plaques characteristic of Alzheimer’s disease (AD) pathology (Mattson, 44 ; De Strooper and Annaert, 19 ). Our study explored whether this was due to elevated BACE1 mRNA. Hepatectomy was associated with an increase of APP and Aβ 1–42 levels on postoperative day 1 and 3 (day 1: P<0. It affects not only muscles but also many organs. Functionally, loss of Mrp14 led to increased phagocytosis of. #hardcore #sex. comは、TikTokのようなアプリの迅速で即座にアクセスできるビデオ配信が好きだが、よりアダルト指向のコンテンツコレクションを好むなら、一見の価値がある。. The interaction networks of each of the 16 target proteins were constructed against 13 causative proteins (APP, PSEN1, PSEN2, APOE, PARK2, SNCA, UCHL1, PARK7, SOD1, ALS2, HTT, ATN1 and PRNP) selected from all six NDs. APP/PS1 mice at 10 months exhibited both individual cell as well as clustered GFAP signals. Hot GIF. If you're looking for some nude videos, you've come to the right. AD Alzheimer’s disease, NFTs neurofibrillary tangles, CAA cerebral amyloid angiopathy. Hot GIF . #squirting GIF . APP/PS1 mice when compared to WT exhibited reduced total GFAP coverage in HPC, which is increased in the EC, while coverage of the clustered GFAP signal in the HPC was increased and accompanied by increased expression of. The forelimb grip strength test (FLGST) was used for functional. Daphnetin (molecular structure shown in Fig. Make Chrome run better. Because it’s your data, we want you to know what Copilot in Windows does with that data. GFAP can search the protein domain, GO and KEGG information for 43000 genes within. If there is anything not clear, please do not hesitate to let me know. If you're looking for some nude videos, you've come to the right. If you're looking for some nude videos, you've come to the right place! OGFAP have best naked videos from TikTok, with same user experience as official app. 606; APP/PS1. The App NL-G-F/NL-G-F mice is a model of AD in which the Aβ sequence within the mouse Aβ precursor protein (APP) has been humanized by changes of 3 amino acids and the Swedish,. Astrocytes are involved in a wide range of CNS pathologies, including trauma, ischemia, and neurodegeneration. The APP Family. Hot GIF. 1. We previously reported that antioxidant treatment can provide protection to the peripheral auditory end organ, the cochlea. Hot GIF . analysis of glial fibrillary acidic protein, metallothionein, and MHC II expression in human, rat and mouse cells. Abstract. mRNA and protein expressions of glial cell markers, neurotrophins, neurotrophin receptors, β-amyloid precursor protein (APP) and the concentrations of pro- and anti-inflammatory cytokines were measured in the hippocampus. Alzheimer's disease is characterized by the extracellular deposition of beta-amyloid peptide (Abeta) in cerebral plaques and evidence is accumulating that amyloid is neurotoxic. Hello y'all. OGFAP have best naked videos from TikTok, with same user experience as official app. Blast-induced traumatic brain injury has dramatically increased in combat troops in today’s military operations. Treatment group: Improved performance in MWM tasks, probe trial, and visible platform tasks (p < 0. Hot GIF . GFAP. Wide range. ThePornDude. ADAD studies strongly indicate that Aβ plays a critical role in AD pathogenesis. The APP/PS1 double transgenic mice develop AD-like cognitive deficits along with aging [22]. Hot GIF. NSFW. At 5'7" and 142 lbs, she's a vivacious. Most commonly, AD presents as a sporadic multi-factorial condition. 5μm (PM2. 5 μM) before PBMT, the Western blotting analysis of the indicated proteins are shown. It is used as a marker to distinguish astrocytes from other glial cells during development. Methods: Hippocampal gene expression of CB2 and GPR55 was explored by qPCR analysis, and brain distribution was evaluated by immunofluorescence in the wild type (WT) and APP knock-in AppNL-G-F AD. Introduction. Glial fibrillary acidic protein (GFAP) is the predominant intermediate filament protein in adult astrocytes. Official Site instagram: She wears her slender figure not as a label but as a testament to her unique journey. In Microsoft Edge in Win11, there is a feature to disable media autoplay. 7K visitors daily, generating a total of 358K pageviews. OGFAP have best naked videos from TikTok, with same user experience as official app. A knockdown of these kinases in SH-SY5Y-APP Sw human neuroblastoma cells reduced amyloid accrual and lowered protein aggregation and associated behavioral traits in C. User account menu. GFAP splice isoforms show differential expression patterns in the human brain. We have identified common potential targets for multi-neurodegenerative disease using insilico approach. If you're looking for some nude videos, you've come to the right place! OGFAP have best naked videos from TikTok, with same user experience as official app. Apl-1 and Appl are the worm and the fly. com Traffic Analysis. We analysed the website and came with a review of ogfap. Все тик ток модели здесь! site ogfap. Basal expression of APP/PS1-induced and APP/PS1-repressed genes is largely unaffected in GFAP-Nrf2 mice (Fig. injected with saline or IL-1β for 1 or 8 days and tested in a radial maze. If a YouTube video, Facebook game, or other media isn't working, try the steps below to fix it. Glia Fibrillary-Associated Protein. Different ages of AD mice and their wild-type littermates (WT) were used in our study. This study explored the effects of particulate matter exposure on AD-related brain changes using the APP/PS1 transgenic model of disease. This equates to about 1. However, plasma GFAP has not. The introduction of highly sensitive immunoassays led to a rapid increase in the number of potential. focal cortical dysplasia. HotOGFAP have best naked videos from TikTok, with same user experience as official app. Now, scientists led by Michael Pontecorvo of Avid Radiopharmaceuticals, a subsidiary of Eli Lily, report that. GFAP mRNA expression is regulated by several nuclear-re. The expression of the cerebral protein GFAP was higher in group II compared with the control group ( P < 0. The engulfed dystrophic neurites were identified by their high content in autophagy vacuoles, and some even were filled with paired-helical filaments corroborating the neuronal origin of these structures. Linear regression analysis (b and c) was performed using the ROD values shown in Figures 2(a), 1(a), and 1(b) for GFAP, APP, and TNFα, respectively. a The protein expressions of cerebral GFAP, APP and Claudin-5 in respective groups. If you're looking for some nude videos, you've come to the right place! OGFAP have best naked videos from TikTok, with same user experience as official app. 88%. 37 In addition to neuronal loss, a hallmark of axonal injury, APP accumulation not only correlates with injury severity and post-TBI outcome, 38,39 but also to impaired synaptic plasticity, and contributes to mTBI. @article{Gao2022DaphnetinAA, title={Daphnetin ameliorates A$eta$ pathogenesis via STAT3/GFAP signaling in an APP/PS1 double-transgenic mouse model of Alzheimer's disease. このサイトはまだ歴史が浅いが、すでにアマチュアの短編動画を幅広くジャンル別に. β-APP is the gold standard of diffuse axonal injury. After removal of the meninges, the external olfactory nerve layers were microdissected and. Hot GIF . If you're looking for some nude videos, you've come to the right place! OGFAP have best naked videos from TikTok, with same user experience as official app. 4M monthly visitors. HotOGFAP have best naked videos from TikTok, with same user experience as official app. Alzheimer’s disease; amyloid-β plaques. r/LipExpansion. Body weight and food intake were recorded weekly (Fig. GFAPδ is preferentially expressed by neurogenic astrocytes in the subventricular zone (SVZ), whereas GFAP(+1) is found in a subset. 37 In addition to neuronal loss, a hallmark of axonal injury, APP accumulation not only correlates with injury severity and post-TBI outcome, 38,39 but also to impaired synaptic plasticity, and contributes to mTBI. Our GFAP monoclonal, polyclonal and recombinant monoclonal antibodies. 更新了: 5月 31, 2023. Hot GIF . c. 8% compared to last month. GFAP is a biomarker for astroglial injury, as is S100β. In ischemic stroke, the greater the damage to neurons and neuroglia, the serum GFAP levels will increase, and there is a relationship between high GFAP levels and the severity of the neurological deficit and the extent of brain damage in ischemic stroke patients. If you're looking for some nude videos, you've come to the right place! OGFAP have best naked videos from TikTok, with same user experience as official app. We have previously shown that ES modulates amyloid-beta pathology and the microglial response to it in the APPswe/PS1dE9 mouse model. Activation of TGFβ1-Smad2/3 signaling by PBMT directs APP/PS1 NSC differentiation into neurons in vitro. Expression of the GFAP gene has attracted considerable attention because its onset is a marker for astrocyte development, its upregulation is a marker for reactive gliosis, and its predominance in astrocytes provides a tool for their genetic manipulation. Ogfap.